Russia launched a series of missile and drone attacks on multiple regions of Ukraine early Saturday, killing at least five people, according to local officials and reports from Agence France-Presse.

The strikes come amid a recent escalation by Moscow following Ukrainian attacks on Russian air bases. Ukrainian authorities reported significant damage and casualties as Russian forces intensified their assault.

The renewed offensive coincides with faltering peace talks held in Istanbul, which ended without agreement on a ceasefire. The war, now in its third year since Russia’s full-scale invasion of Ukraine in February 2022, shows no signs of abating as both sides continue to trade heavy blows on the front lines.